[Animal Modeling - Pharmacological Evaluation] - Lipopolysaccharide induced Acute Renal Failure Model

Adult male rats weighing 200-300g; Medications: Anesthetic, inulin, Escherichia coli lipopolysaccharide (LPS)...

2024-09-13

【Animal modeling drug efficacy evaluation】 - acute renal failure model induced by denatured hemoglobin

Animals: Healthy adult rats, male and female not included; Medications: human blood, physiological saline, 50:50 alcohol and dry ice mixture, distilled water, potassium ferrocyanide, Dowex 50-8...

2024-09-13

【Animal Modeling】 - Acute Necrotizing Pancreatitis Model in Dogs

Adult hybrid dog, 10-15kg, male and female unlimited; Medications: Trypsin, pentobarbital...

2024-09-12

【Animal Modeling】-Expression of NF-κB in Hepatocytes of Rats with Welfare Injury Induced by Braking

To study the expression changes of NF-κB in hepatocytes of rats with welfare injury induced by immobilization...

2024-09-12

[Animal modeling] - Comparative study on pharmacokinetics of Eucommia ulmoides extract in normal rats and SHR models after repeated administration

To study the pharmacokinetic differences of 7 active components of eucommia ulmoides extract after repeated administration in normal rats and spontaneously hypertensive rats, namely, pinoresinol diglucoside, geniposide, chlorogenic acid, protocatechu...

2024-09-12

【Animal modeling drug efficacy evaluation】 - Doxorubicin induced toxic acute renal failure model

Under the action of drug metabolizing enzymes in the body, doxorubicin forms semiquinone radicals, which react with oxidation to generate superoxide anions and hydroxyl radicals. Both can cause damage to the kidneys through membrane lipid peroxidatio...

2024-09-09

[Animal modeling drug efficacy evaluation] - electrocoagulation method for replicating rat myocardial infarction model

Wistar rats, male or female, weighing 150-250g; Medications: Ketamine, Penicillin; Equipment: BL-420 biological function experimental system, animal artificial ventilator, 1411 small high-frequency knife...

2024-09-06

[Animal Modeling - Pharmacological Evaluation] - Experimental Small Pig Chronic Myocardial Ischemia Model

Animal: Small pigs for health experiments, weighing (22.64 ± 4.3) kg, male or female not limited; Medications: Ketamine, Atropine, Pentobarbital, Isoflurane, Nitroglycerin, Penicillin; Equipment: ECG monitor...

2024-09-06

[Animal Modeling Drug Efficacy Evaluation ]- Pneumocystis carinii Infection Animal Model

Pneumocystis carinii is an important opportunistic parasitic infection that can cause fatal pneumonia in immunocompromised patients...

2024-09-06

【Animal modeling - Drug efficacy evaluation】 - Cisplatin induced moderate toxicity acute renal failure model

Animals were adaptively fed for one week before use in the experiment. Cisplatin was diluted to 2mg/ml with distilled water before the experiment. Inject 6mg/kg cisplatin (2mg/ml distilled water) via the tail vein of rats or dissolve 10mg/kg cisplati...

2024-09-06

[Animal modeling - Drug efficacy evaluation] - Hypertension model induced by medullary nerve compression

After routine anesthesia in adult experimental dogs, tracheal intubation was performed, and a right femoral artery intubation was performed. A multi-channel physiological recorder was connected to monitor blood pressure...

2024-09-05

[Animal modeling - Drug efficacy evaluation] - Balloon injury leading to aortic thrombosis

After routine anesthesia, the experimental rabbits were fixed and one side of the femoral artery and vein were separated. 20ml of blood was collected through femoral vein catheterization, and platelets were labeled with 51Cr...

2024-09-05

[Animal modeling drug efficacy evaluation] - replication of disseminated intravascular coagulation model using rabbit brain powder infusion

　　Preparation of rabbit brain powder infusion: euthanize the rabbit by bloodletting, remove the rabbit brain, clean the attached blood vessels and meninges, rinse it clean, and then use gauze to absorb it. Place it in a mortar and add acetone. Grind ...

2024-09-05

【Animal Modeling - Pharmacological Evaluation】 - Acute Renal Failure Model Induced by Oleic Acid

rats, weighing 220-250g; Drug: Oleic acid...

2024-09-05

[Animal modeling] - establishment of a traumatic epilepsy animal model by cortical injection of ferrous chloride

Healthy adult male SD rats, weighing 180-220g; Medication: 10% chloral hydrate, FeCl2 solution...

2024-09-05

【Animal modeling】-Effects of bile duct ligation and recanalization on the phenotype and NOX4 protein expression in rat liver

To design and establish a rat liver fibrosis model with bile duct ligation and recanalization, and to observe the effects of bile duct ligation and recanalization on epithelial-mesenchymal phenotype and oxidative stress-related protein expression in...

2024-09-05