[Animal modeling - Drug efficacy evaluation ]- Method for replicating tumor models

There are many methods to replicate animal tumors, such as irradiating experimental animals with radiation or injecting radioactive isotopes intravenously or locally; Using various chemical carcinogens (alkylating agents, polycyclic aromatic hydrocar...

2024-07-30

[Animal Modeling - Efficacy Evaluation] - Spontaneous Vitiligo Animal Model

Some animals (such as chickens, rodents, dogs, cats, and horses) can be artificially induced to experience local depigmentation. These animals often have anti melanocyte antibodies in their bodies, with the most commonly used being Smyth line (SL) ch...

2024-07-30

[Animal Modeling - Efficacy Evaluation] - Hepatitis A Virus Tree Shrew Model

Take the stool of a hepatitis A patient with positive hepatitis A antigen, prepare a 5% suspension, and centrifuge at 3000 and 8000 rpm for 30 minutes respectively. The supernatant is frozen at -80 ℃ for later use. Adult healthy tree shrews were oral...

2024-07-30

[Animal Modeling - Pharmacological Evaluation] - Mouse Focal Cerebral Ischemia Model

Healthy male 2nd grade Kunming mice, weighing 12-22g; Medications: Pentobarbital, 2,3,5-triphenyltetrazolium chloride...

2024-07-30

【Animal Modeling - Pharmacological Evaluation】 - Canine Acute Myocardial Ischemia Model

Healthy hybrid dogs, each weighing between 15-20 kg; Medications: Ketamine, Sodium Barbital; Equipment: BL-420 biological function experimental system, animal artificial ventilator...

2024-07-29

[Animal modeling - Drug efficacy evaluation] - Verapamil induced bradycardia model

mice, weighing 25-40g, both male and female; Medication: 10% urinary ester, verapamil...

2024-07-29

[Animal Modeling Drug Efficacy Evaluation ]- Rat Uveitis Model Induced by Salmonella Toxins

　　SD rats, grade 2, 6-8 weeks old, weighing 150-180g, male. The endotoxin used was Salmonella typhi endotoxin (LPS, Sigma). The endotoxin was dissolved in sterile physiological saline at a concentration of 2g/L. 50 μ l of endotoxin was injected into ...

2024-07-29

[Animal Modeling Drug Efficacy Evaluation] - Spinal cord or white matter homogenate as antigen induces EAE model

Female Wistar rats, 6-8 weeks old, weighing 130-200g; Guinea pig, female, weighing 330-400g. Reagents. BCG freeze-dried powder, pertussis vaccine, complete Freund\'s adjuvant. Before using the complete Freund\'s adjuvant, add the freeze-dried powder ...

2024-07-29

【Animal Modeling - Pharmacological Evaluation 】- High Fat Feed Induced Hyperlipidemia Animal Model in Rabbits

rabbits, male or female not limited; Medication: High fat feed...

2024-07-29

[Animal Modeling - Pharmacological Evaluation] - Preparation of Cerebral Ischemia Model in Rats with Autologous Thrombosis Combined with Thread Thrombosis Blocking the Middle Cerebral Artery

SD rats, 2-3 months old, half male and half female, with an average weight of (300 ± 50) g; Medications: Chloral hydrate, thrombin...

2024-07-29

[Animal modeling - Drug efficacy evaluation ]- Preparation of influenza virus infection secondary pneumococcal pneumonia model

In the ranking of human disease mortality rates, bacterial pneumonia and influenza rank sixth. Animal models can be used to study the mechanism of interaction between influenza and pneumococcal bacteria...

2024-07-29

[Animal Modeling - Pharmacological Evaluation] - In vivo Thrombosis Animal Model

Wistar rats, male or female, weighing 200-250g; Medications: Ethyl carbamate, heparin injection; Equipment: Disposable intravenous catheter, BL-420 biological function experimental system...

2024-07-29

[Animal Modeling - Pharmacological Evaluation] - Coronary Artery Quantitative Stenosis and Blood Stasis Syndrome Animal Model

Adult experimental dogs were anesthetized and underwent positive pressure artificial respiration with endotracheal intubation. The fifth rib of the left chest was incised, a heart bag was cut, and a pericardial bed was made. The coronary artery was s...

2024-07-29

[Animal Modeling - Pharmacological Evaluation] - Low Selenium Mouse Model of Viral myocarditis

Selenium was discovered over 180 years ago, initially for its toxic effects on the liver. Later, it was found that selenium is essential for the growth of animals and humans at low concentrations, and toxic at high concentrations...

2024-07-29

Animal Modeling Drug Efficacy Evaluation Reflux Gastritis Model

Male rats weighing 200-250g; Medications: Pentobarbital, physiological saline, iodine...

2024-07-29

Animal Modeling Drug Efficacy Evaluation Autoimmune Antibody Passive Transport Model

IgG was taken from patients with bullous pemphigoid (BP) and injected into the cornea of New Zealand rabbits. After 24 hours, epidermal separation, thickening, and blister formation appeared on the cornea. The inflammatory response is dose-dependent,...

2024-07-29