[Animal modeling] Reproduction and identification of sick sinus syndrome disease model constructed by miR-5572 transgenic mice

To investigate the feasibility of constructing sick sinus syndrome disease model in miR-5572 transgenic mice...

2023-12-14

【Animal Model】-Continuous 5-day REM sleep deprivation induces delayed-onset depression-like behavior in mice

To investigate the effect of continuous long-term rapid eye movement sleep deprivation (5 d) on depression-like behavior and the level of amygdala monoamine oxidase A in C57BL/6J mice...

2023-12-14

[Animal modeling] - Characteristics of changes in articular cartilage and subchondral bone in different animal models of osteoarthritis

To investigate the pathological changes of subchondral bone and articular cartilage in different animal models of osteoarthritis...

2023-12-13

【Animal modeling】The effect and mechanism of -2,3-butanedione monooxime in improving abnormal calcium injury in isolated rat heart

To investigate the effect and mechanism of contracture inhibitor 2,3-butanedione monooxime in improving abnormal calcium injury in isolated rat hearts...

2023-12-12

【Animal modeling】- Establishment of SD rat limb ischemia-reperfusion injury model

To introduce an improved method of blocking femoral artery blood flow in vitro, and to establish a simple, controllable and reliable model of limb ischemia-reperfusion injury in rats...

2023-12-12

【Animal Modeling】-Albino C57BL/6N Mice Made by CRISPR-Cas9 Knockout of Tyr Gene

To obtain albino C57BL/6N mice and expand their application in skin transplantation and embryonic stem cell research...

2023-12-12

【Animal modeling】-Effect of geniposide on the expression of IL-6, TNF-α and IL-1β in animal models of mastitis

To investigate the effect of geniposide on the expression of IL-6, TNF-α and IL-1β in mammary tissue and mammary epithelial cells of mastitis mice...

2023-12-11

【Animal Modeling】-miR-122 Expression Changes and Action Mechanisms in Kidney Tissues of Mice with Diabetic Nephropathy

To investigate the expression changes of miR-122 in the kidney tissue of diabetic nephropathy mice and the effect and possible mechanism of silencing miR-122 on the kidney tissue of DN mice...

2023-12-11

【Animal Modeling】-Exploration of the evaluation method of the rat model of precocious puberty with phlegm-damp stagnation syndrome

To explore the method of systematic review of the rat model of precocious puberty with phlegm-damp stagnation syndrome...

2023-12-11

【Animal Modeling】-Research on the antidepressant mechanism of licorice and its application in animal behavior

Depression, also known as \\\"emotional cold\\\", is a common affective disorder characterized by persistent low mood. The clinical manifestations are depression, loss of various interests and pleasures, and are often accompanied by physica...

2023-12-11

【Animal modeling】-Solanine inhibits the growth of nude mouse prostate cancer cell Du145 xenografts by inducing cell cycle G1/S arrest

To investigate the effect and molecular mechanism of solanine on the growth of prostate cancer cell Du145 transplanted in nude mice...

2023-12-08

【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

To investigate the changes and significance of malondialdehyde, superoxide dismutase and interleukin-6 in lung tissue of acute hypoxia-induced acute pulmonary edema in rats...

2023-12-08

【Animal Modeling】-Comparison of different methods of making visceral hypersensitivity models of irritable bowel syndrome

To study different methods to make IBS visceral hypersensitivity mouse model, and to evaluate its visceral sensitivity and stability...

2023-12-08

【Animal modeling】-5-Fluorouracil combined with mechanical scratching-induced oral mucositis model in golden hamsters

To establish a model of oral mucositis in golden hamsters induced by 5-fluorouracil combined with mechanical scratching...

2023-12-08

【Animal Modeling】-Establishment of a Drosophila Heart Failure Model Induced by High-fat Diet

To establish a model of Drosophila heart failure induced by high-fat diet...

2023-12-07

【Animal modeling】-The effect of targeted inhibition of macrophage Act1 expression on ulcerative colitis

To investigate the role of macrophage NF-κB activating factor 1 in inflammatory bowel disease...

2023-12-07