【Animal Modeling】-Establishment and mechanism of high-fat and high-salt diet-induced hypertension model in Bama miniature pigs

To establish a hypertensive model of Bama miniature pigs with a high-fat and high-salt diet, and to explore its possible pathogenesis...

2024-05-07

[Animal modeling] - construction of a bioluminescent human liver cancer nude mouse in situ cancer model

To select a stable expression of luciferase reporter gene in human liver cancer cell line (HCCLM3 Luc) and construct a nude mouse model of in situ cancer bearing human liver cancer cell line...

2024-05-06

[Animal modeling] - Study on the rat model of atherosclerosis (Qi stagnation and blood stasis syndrome) combined with disease and syndrome

To construct a rat model of atherosclerosis combining disease and syndrome, and to provide an evaluation tool for the pharmacodynamics research of corresponding Chinese herbal formulas...

2024-05-06

[Animal modeling] - establishment of a canine atrial fibrillation model using high-frequency right atrial pacing and evaluation of implantable electrocardiogram monitors

To observe the efficiency and safety of establishing an atrial fibrillation model by innovatively using fine electrode wires, advanced catheter manipulation systems, and implantable electrocardiogram monitors in traditional high-frequency atrial paci...

2024-05-06

[Animal Modeling]- TNF Based on Gene Chips- α Bioinformatics analysis of induced osteoarthritis cell model

Osteoarthritis is the most common degenerative chronic joint disease, but its specific genetic mechanism is still not fully understood. By using gene chips to detect changes in gene expression profiles of OA cell models, more biological basis is prov...

2024-05-06

Establishment of an animal model of CA16 infection in tree shrew lung fibroblasts and expression of its receptor SCARB2

To explore the feasibility of establishing an experimental model of CA16 infection in tree shrew lung fibroblasts...

2024-05-06

[Animal Modeling] - Aseptic APPswe/PS1 Δ Establishment of E9 double transgenic mouse model and preliminary observation of changes in brain plaques

To establish a sterile APPswe/PS1 using a cesarean section purification method Δ E9 (PAP) dual transgenic mouse model and preliminary observation of plaque deposition in the animal brain, providing a new animal model for studying the relationship bet...

2024-05-06

[Animal modeling] - Characteristics of changes in articular cartilage and subchondral bone in different animal models of osteoarthritis

To explore the pathological changes of subchondral bone and articular cartilage in different animal models of osteoarthritis...

2024-05-06

[Animal Modeling] - Using Orthogonal Experiments to Optimize and Establish a Rat Conditional Fear Memory Model

To optimize the optimal experimental parameters and search for the optimal experimental conditions for establishing a rat conditioned fear memory model using orthogonal experiments...

2024-05-06

[Animal Modeling] - Application Analysis of Acute Liver Injury Animal Models Based on Data Mining

To explore the modeling elements of various acute liver injury animal models, and provide reference and suggestions for the establishment and evaluation of acute liver injury animal models...

2024-05-06

【Animal modeling】-Efficacy observation and action pathway of Eucommia ulmoides extract on lipopolysaccharide-induced mastitis mice

To study the therapeutic effect and mechanism of Eucommia ulmoides extract on mastitis in mice...

2024-04-30

【Animal modeling】-β-aminopropionitrile-induced rat model of dissecting aneurysm establishment

To explore the effect of β-aminopropionitrile on the wall of the aorta in mice, and to compare the pathogenesis of human dissecting aneurysm, in order to further explore the animal model of dissecting aneurysm with the characteristics of human diseas...

2024-04-30

【Animal Modeling】-Comparative study on the establishment of allergic conjunctivitis mouse models under different conditions

To establish a mouse model of allergic conjunctivitis under the conditions of different antigens, different stimulation routes and different ages of mice. The establishment provides new ideas and methods...

2024-04-30

【Animal modeling】-Comparison of imiquimod on the induction of psoriasis-like skin lesions in BALB/c and C57BL/6 mice

To observe the difference and mechanism of imiquimod in the induction of psoriasis-like skin lesions in different strains of mice...

2024-04-29

[Animal modeling] - Establishment of a mouse model of pregnancy diabetes induced by high-fat diet combined with STZ

To explore a stable and reliable method for establishing a mouse model similar to gestational insulin resistance...

2024-04-28

[Animal modeling] - Optimization of AOM/DSS colon cancer model and exploration of changes in gut microbiota

To optimize the method of modeling colitis associated colon cancer using oxidized azomethane combined with sodium gluconate sulfate and explore the pathogenesis of gut microbiota in CAC...

2024-04-28