[Animal Modeling Drug Efficacy Evaluation] - Canine Orthodontic Wire Ligation with Mechanical Injury Periodontitis Animal Model

The clinical characteristics of periodontitis mainly include gingival inflammation, periodontal pocket formation, alveolar bone resorption, and tooth loosening and displacement. Among them, how to prevent further alveolar bone resorption and promote ...

2024-08-01

[Animal Modeling - Pharmacological Evaluation] - Ovarian Resection Induced Osteoporosis Animal Model

Primary osteoporosis includes postmenopausal osteoporosis and senile osteoporosis, mainly characterized by decreased bone mass, degeneration of bone microstructure, decreased bone strength and increased fragility, and susceptibility to fractures. The...

2024-08-01

[Animal Modeling Drug Efficacy ]Evaluation Allergic Conjunctivitis Model

Eye hypersensitivity is mainly a type I hypersensitivity reaction mediated by mast cells. Hericidal conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and macromastic keratoconjunctivitis are mainly involved in type I allergic ...

2024-08-01

[Animal Modeling - Pharmacological Evaluation] - Low Eye Pressure Glaucoma Disease Animal Model

Low intraocular pressure can cause damage to eye tissue. Long term low intraocular pressure can cause papilledema, retinal hemorrhage, exudation, and radial wrinkles in the macula. The optic disc is a part of the central nervous system, not periphera...

2024-08-01

[Animal Modeling Drug Efficacy]- Evaluation Activated Lymphocytes and Their Chromatin Induced SLE Mouse Model

Using activated lymphocytes from inbred mice as antigens to immunize homologous mice can induce the host to produce self anti dsDNA antibodies, anti nuclear antibodies, etc. Antigen antibody complexes deposit in renal tissue, causing immune complex g...

2024-08-01

[Animal Modeling Drug Efficacy Evaluation]- Induced Hyperthyroidism Animal Model

By orally administering or injecting thyroid hormone, artificially increasing the thyroid hormone content in animals can cause them to exhibit various symptoms of hyperthyroidism...

2024-08-01

[Animal Modeling - Pharmacological Evaluation] - Non bacterial Prostatitis Animal Model

Chronic non bacterial prostatitis may be caused by mycoplasma, chlamydia, and autoimmune diseases, which are very similar and non-specific to the clinical symptoms of chronic bacterial prostatitis. The main symptoms include urgency to urinate, pain d...

2024-08-01

[Animal Modeling Drug Efficacy Evaluation] - Human Ovarian Cancer Transplanted Tumor Model in Nude Mice

The nude mouse transplantation model of human ovarian cancer is an ideal carrier for ovarian cancer research, which has important applications in the etiology, pathogenesis, biological characteristics, radioimmunoassay diagnosis, screening of chemoth...

2024-08-01

[Animal Modeling - Efficacy Evaluation] - Transgenic Cervical Cancer Animal Model

Currently, over 200 subtypes of HPV have been identified, of which about 40 subtypes can infect the reproductive tract and be transmitted through sexual contact...

2024-08-01

[Animal Modeling - Pharmacological Evaluation] - Induced Ovarian Cancer Animal Model

Chemical carcinogens are directly applied to tissues through local embedding and other methods. These carcinogens act on the surface epithelium of the ovary, causing cell transformation. At the same time, they may also cause ovarian tumors by damagin...

2024-08-01

【Animal Modeling - Pharmacological Evaluation】 - Chemical Induced IBD Animal Model

The chemical induction method started early and has become the most mature and commonly used method for preparing IBD models since the 1960s. There are many types of chemical irritants, including acetic acid, sodium dextran sulfate, sodium peroxynitr...

2024-08-01

【Animal Modeling - Pharmacological Evaluation】 - H2O2 Induced Arterial Thrombosis Animal Model

The replication method involves separating the common carotid artery and femoral artery on both sides of the experimental rabbit after routine anesthesia, and clamping the ends of one common carotid artery with two arteries at a distance of about 2.5...

2024-07-31

[Animal modeling - Drug efficacy evaluation ]- Extrarenal bandaging induced hypertension model

Also known as extrarenal compression hypertension model, it can be divided into two kidney one bundle type (one kidney bundle, bilateral kidney preservation), one kidney one bundle type (one kidney bundle, contralateral kidney resection), and two kid...

2024-07-31

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Canine Chronic Myocardial Ischemia and Infarction Model with Chest Closure

The replication method was performed on experimental dogs weighing 10-15kg. After routine anesthesia, Seldinger technique was used to deliver self-made polyvinyl chloride constrictors (including effective stenosis length of 10mm) through the right fe...

2024-07-31

[Animal modeling - Drug efficacy evaluation] - Microsphere injection induces myocardial ischemia

Take experimental dogs weighing about 30kg and administer intravenous injection of phenobarbital sodium at a dose of 35-40mg/kg body weight for anesthesia, while maintaining anesthesia at 4mg/(kg · h). Animal\'s right lateral position fixed, tracheal...

2024-07-31

[Animal modeling - Drug efficacy evaluation] - Drug induced myocardial ischemia

Rats weighing around 200g (excluding animals with abnormal electrocardiograms) were subjected to myocardial ischemia induced by posterior pituitary hormone. The rats were injected with posterior pituitary hormone via sublingual or tail vein at a dose...

2024-07-31